Author Topic: Coronavirus: corona, meaning "crown" or "halo"  (Read 115 times)

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Coronavirus: corona, meaning "crown" or "halo"
« on: June 11, 2021, 11:55:26 PM »
Coronavirus: corona, meaning "crown" or "halo"


Coronavirus genomes also encode a protein called RNA-dependent RNA polymerase (RdRp), which allows the viral genome to be transcribed into new RNA copies using the host cell's machinery. The RdRp is the first protein to be made; once the gene encoding the RdRp is translated, translation is stopped by a stop codon. This is known as a nested transcript. When the mRNA transcript only encodes one gene, it is monocistronic. Coronavirus non-structural proteins provide extra fidelity to replication, because they confer a proofreading function, which is lacking in RNA-dependent RNA polymerase enzymes alone.

ARTICLE

Associations between blood type and COVID-19
infection, intubation, and death Michael Zietz 1, Jason Zucker 2 & Nicholas P. Tatonetti 1,2,3,4

The rapid global spread of the novel coronavirus SARS-CoV-2 has strained healthcare and testing resources, making the identication and prioritization of individuals most at-risk a critical challenge. Recent evidence suggests blood type may affect risk of severe COVID-19. Here, we use observational healthcare data on 14,112 individuals tested for SARS-CoV-2 with known blood type in the New York Presbyterian (NYP) hospital system to assess the association between ABO and Rh blood types and infection, intubation, and death. We ?nd slightly increased infection prevalence among non-O types. Risk of intubation was decreased among A and increased among AB and B types, compared with type O, while risk of death was increased for type AB and decreased for types A and B. We estimate Rh-negative blood type to have a protective effect for all three outcomes. Our results add to the growing body of evidence suggesting blood type may play a role in COVID-19.

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